Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke-Blackburn-Bienaymé reaction and their Hsp90 inhibitory activity.

نویسندگان

  • Jing Ren
  • Min Yang
  • Hongchun Liu
  • Danyan Cao
  • Danqi Chen
  • Jian Li
  • Le Tang
  • Jianhua He
  • Yue-Lei Chen
  • Meiyu Geng
  • Bing Xiong
  • Jingkang Shen
چکیده

Using a 2,3-diamino pyrazine substrate and yttrium triflate catalyst, various 2-alkyl and aryl substituted 3,8-diaminoimidazo[1,2-a]pyrazines were efficiently prepared through Groebke-Blackburn-Bienaymé MCR. In particular, a novel 2-piperonyl 3,8-diaminoimidazo[1,2-a]pyrazine structure was prepared exclusively with this new method and was found to have moderate Hsp90 inhibitory activity. A crystalline complex with N-terminus ATP domain of Hsp90 and one of the new Hsp90 inhibitors was also obtained to elucidate the origin of activity of 2-piperonyl 3,8-diaminoimidazo[1,2-a]pyrazines.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 13 5  شماره 

صفحات  -

تاریخ انتشار 2015